Report about this paper In Vitro Activities of Synthetic Host Defense Assignment

Report about this paper In Vitro Activities of Synthetic Host Defense Propeptides Processed by Neutrophil Elastase against Cystic Fibrosis Pathogens - Assignment Example The potential of HDPs as multifunctional effectors of innate immunity in higher organism provides the impetus and motivation for the progress in their research. The research paper being summarized in this report is In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens authored by Stephen Desgranges, Florie Le Prieult, Alan Daly’ Jeniffer Lydon, Marian Brennan, Dilip K. Rai, Anusha P. Subasinghage, Chandralal M. Hewage, Sally-Ann Cryan, Catherine Greene, Noel G. McElvaney, Timothy P. Symth and Marc Devocelle. This paper was published in the journal Antimicrobial agents and chemotherapy under the American society for microbiology on May 2011. The journal has an impact factor of 4.672, a respectable impact factor for any reputable journal. Publishing of the work was significant to shed light on light on activities of synthetic host defense propeptides firsthand and hinder other person/groups doing so first. The Desgranges et al have undertaken a study where they have reported the in vitro activities of synthetic host defense propeptides against cystic pathogens namely Staphylococcus aureus and Pseudomonas aeruginosa ­ [2]. This paper focuses on the effect of modifying the propeptide by reducing the net change on the antimicrobial and haemolytic activity. The aim of this work by Desgranges et al was to utilize the abnormal amounts of neutrophil elastase present in cystic fibrosis to process several synthetic prodrugs against common pathogens in cystic fibrosis, P. aeruginosa and S. aureus [2]. Peptides are present in many living systems and are utilized by the innate immune systems to combat invading pathogens. Therefore this study aims at constructing a propeptide that will be able to evade the host immune system and also be a substrate for the all abundant neutrophil elastase present in cystic fibrosis lung. Since peptides